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Methyl chloride is clearly genotoxic in both bacteria and mammalian cells. Methyl chloride can bind to protein. However, if methyl chloride is an alkylating agent, it is so to a very small extent. Further, methyl chloride might be considered only a very weak mutagen in in vivo in this regards.

Pesticides are the most frequently used group of chemical substances used in the environment, and based on the magnitude of use, it is considered that a significant number of these are found in the soil, water, and air. Because of its high toxicity and persistence in the environment, many pesticides are potential human health hazards, even when used properly. Exposure to pesticides can occur through several routes, including ingestion, inhalation, absorption through the skin, and application to the body surface. The main route of exposure of pesticides to people in the United States is through ingestion of contaminated food and beverages, and the National Academy of Science report has estimated that lifetime dietary intake is the most significant contributor to the total contaminant burden for pesticides in the United States, accounting for about 90% of total dietary intake. Almost three billion pounds of pesticides are used annually in the United States. The single most commonly used chemical, atrazine, is used in the U.S. on more than 30 million acres/year to control unwanted weeds in agriculture, and 70% of the atrazine registered for use is applied to corn crops that are then fed to cattle and other livestock.

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